Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism
نویسندگان
چکیده
منابع مشابه
Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum
BACKGROUND Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton ru...
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In this study, the antifungal activities of limonene against Trichophyton rubrum were evaluated via broth microdilution and vapor contact assays. In both assays, limonene was shown to exert a potent antifungal effect against T. rubrum. The volatile vapor of limonene at concentrations above 1 µl/800 ml air space strongly inhibited the growth of T. rubrum. The MIC value was 0.5% v/v in the broth ...
متن کاملRegulation of Trichophyton rubrum proteolytic activity.
Trichophyton rubrum is the most common dermatophyte of humans and normally colonizes the superficial layers of the epidermis (stratum corneum). Several proteinases with a possible role in the metabolism of host proteins have been purified from this fungus. The regulation of these enzymes and their role in fungal metabolism were studied at the biochemical level. General proteolytic (azocollytic)...
متن کاملEffects of Fatty Acid Salts against Trichophyton Violaceum
Trichophyton violaceum is an anthropophilic fungus. Dermatophytosis (Tinea) is fungal infection that can infect the scalp, glabrous skin, and nails. In general, Tinea can be spread by skin-to-skin contact or bathroom or floor materials. The treatments of Tinea need antifungal medication and good hygiene environment. The effective antifungal medication and infection prevention, and the creation ...
متن کاملAntifungal activity of flavonoids and modulation of expression of genes of fatty acid synthesis in the dermatophyte Trichophyton rubrum
Background Dermatophytosis are fungal infections caused by keratinophilic fungi known as dermatophytes and classified in three genera: Trichophyton, Epidermophyton and Microsporum. Trichophyton rubrum is the most frequent species associated to dermatophytosis worldwide [1]. The infections caused by dermatophytes are not lethal, but are difficult to treat and uncomfortable. In the case of T. rub...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2019
ISSN: 1471-2164
DOI: 10.1186/s12864-019-5792-0